Copper-catalyzed enantioselective C-H functionalization of indoles with an axially chiral bipyridine ligand.
نویسندگان
چکیده
Using copper complexes with an axially chiral bipyridine ligand C4-ACBP as the catalyst, an enantioselective functionalization of indoles with diazo compounds was developed with up to 95% ee. This protocol paves the way for further applications of these ligands.
منابع مشابه
Iron-Catalyzed C H Fuctionalization of Indoles
An easily available iron catalyst was developed to accomplish the C H functionalization of indoles with a-aryl-a-diazoesters in high yields under mild conditions. The asymmetric C H functionalization of indoles was also realized by using iron complexes of chiral spiro bisoxazolines with up to 78% ee.
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Title Catalytic enantioselective C-H functionalization of indoles with α-diazopropionates using chiral dirhodium(II) carboxylates : asymmetric synthesis of the (+)-α-methyl-3-indolylacetic acid fragment of acremoauxin A Author(s) Goto, Takayuki; Natori, Yoshihiro; Takeda, Koji; Nambu, Hisanori; Hashimoto, Shunichi Citation Tetrahedron : Asymmetry, 22(8): 907-915 Issue Date 2011-04-30 Doc URL ht...
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 14 35 شماره
صفحات -
تاریخ انتشار 2016